U.S. Poison Centers have received reports of serious health effects associated with 7-OH (7-hydroxymitragynine), a strong chemical found in the kratom plant. Kratom has been used for its stimulant and opioid-like effects. It is often sold as powders, teas, pills, edibles, or liquid extracts. Products containing Kratom or 7-OH are sometimes marketed as natural remedies for pain, anxiety, or to help with opioid withdrawal. Kratom and 7-OH do not have FDA-approved medical use, and products containing 7-OH have not been proven to be safe or effective. Recently, the U.S. Food and Drug Administration (FDA) announced they have taken steps to restrict access to 7-OH products due to its strong opioid effects and continue to monitor reports of adverse effects.

From January 1-July 31, 2025 Poison Centers have received 1,690 reports of exposure cases involving Kratom; this total has already passed the total from all of 2024. This trend includes a rising number of cases involving 7-OH.

In 2025, there have been 165 reports of exposures to 7-OH. Of patients reporting exposure to 7-OH alone, 35% had serious health problems and 67% were treated at a healthcare facility.

Symptoms reported after 7-OH use include:

• Nausea and vomiting
• Agitation
• Confusion
• Sweating
• Rapid heart rate
• High blood pressure
• Trouble breathing
• Sleepiness or loss of consciousness
• Seizures

America’s Poison Centers advises the public to:

• Avoid products containing 7-OH.Some kratom products have been found to contain potentially dangerous amounts of 7-OH. These products are not tested for safety or effectiveness and are not approved by the FDA to treat any medical conditions.
• Keep all herbal products away from children and pets.
• Talk to a doctor or pharmacist before using any supplements, especially ones marketed for pain, energy, or mood.
• Report any bad reactionsto your local Poison Control Center at 1-800-222-1222 or visit PoisonHelp.org.